Um Honey: A Natural Antimicrobial in Pharmaceutical Pratice
Keywords:
ação antimicrobiana; propriedades medicinais; microrganismos; o uso do mel.Abstract
Honey, known for its medicinal properties in traditional medical practice, has brought a new focus in modern pharmaceutical practice as a potential natural antimicrobial. The use of honey as an antimicrobial agent is nothing new; it has always been used historically as an anti-infective and wound-healing agent, and modern research certainly does not disappoint in revealing the mechanisms of antimicrobial action. Honey is rich in phenolic compounds, which play a crucial role. In fact, these compounds have been proven to be substances responsible for honey's antibacterial activity and can prevent the growth of various pathogenic microorganisms (Cianciosi et al., 2018). Regarding the types of honey, Manuka honey is the most popular due to its high content of methylglyoxal, a compound with impressive antimicrobial properties, capable of killing even bacterial strains that are resistant to the effects of antibiotics (Johnston et al., 2018; Dahiya et al., 2024). A review by Kwakman and Zaat (2012) supported that honey contains many antibacterial compounds that together can contribute to fighting infections. Along with its bacteria-fighting qualities, honey has been shown to exhibit wound healing and treatment qualities. The use of honey to heal wounds has been established as effective for controlling inflammation and promoting tissue regeneration (Minden-Birkenmaier & Bowlin, 2018). Mandal and Mandal (2011) in one of their articles discuss the role of honey as a substitute for synthetic antimicrobials, as well as the authenticity of the pharmaceutical and clinical use of honey. Although the use of honey for pharmaceutical purposes is highly promising, there is still a need for standardization to a certain extent, since the manufacture of medicines must be safe and effective. The document instructs the authorities to strictly control and standardize the use of honey for restricted therapeutic purposes in order to achieve maximum efficacy. In a word, the literature review is clear on the indications that honey has potential antimicrobial qualities and can therefore be applied to the health field. However, much more research is needed to establish clear guidelines on how to apply them in clinical health and ensure that pharmaceutical products with honey are safe, effective and properly regulated.
References
Bibliografia
CIANCIOSI, D. et al. Phenolic compounds in honey and their associated health benefits: A review. Molecules (Basel, Switzerland), v. 23, n. 9, p. 2322, 2018.
DAHIYA, D.; MACKIN, C.; NIGAM, P. S. Studies on bioactivities of Manuka and regional varieties of honey for their potential use as natural antibiotic agents for infection control related to wound healing and in pharmaceutical formulations. AIMS microbiology, v. 10, n. 2, p. 288–310, 2024.
JOHNSTON, M. et al. Antibacterial activity of Manuka honey and its components: An overview. AIMS microbiology, v. 4, n. 4, p. 655–664, 2018.
KWAKMAN, P. H. S.; ZAAT, S. A. J. Antibacterial components of honey. IUBMB life, v. 64, n. 1, p. 48–55, 2012.
MANDAL, M. D.; MANDAL, S. Honey: its medicinal property and antibacterial activity. Asian pacific journal of tropical biomedicine, v. 1, n. 2, p. 154–160, 2011.
MINDEN-BIRKENMAIER, B. A.; BOWLIN, G. L. Honey-based templates in wound healing and tissue engineering. Bioengineering (Basel, Switzerland), v. 5, n. 2, p. 46, 2018.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Samuel Ventura, Assys, Thyago, Mateus (Autor)
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Termo de cessão de direitos autorias
Esta é uma revista de acesso livre, em que, utiliza o termo de cessão seguindo a lei nº 9.610/1998, que altera, atualiza e consolida a legislação sobre direitos autorais no Brasil.
O(s) autor(es) doravante designado(s) CEDENTE, por meio desta, publica a OBRA no Caderno Verde de Agroecologia e Desenvolvimento Sustentável, representada pelo Grupo Verde de Agroecologia e Abelhas (GVAA), estabelecida na Rua Vicente Alves da Silva, 101, Bairro Petrópolis, Cidade de Pombal, Paraíba, Brasil. Caixa Postal 54 CEP 58840-000 doravante designada CESSIONÁRIA, nas condições descritas a seguir:
O CEDENTE declara que é (são) autor(es) e titular(es) da propriedade dos direitos autorais da OBRA submetida.
O CEDENTE declara que a OBRA não infringe direitos autorais e/ou outros direitos de propriedade de terceiros, que a divulgação de imagens (caso as mesmas existam) foi autorizada e que assume integral responsabilidade moral e/ou patrimonial, pelo seu conteúdo, perante terceiros.
O CEDENTE mantêm os direitos autorais e concedem à revista o direito de divulgação da OBRA, com o trabalho simultaneamente licenciado sob a Licença Creative Commons do tipo atribuição CC-BY.
O CEDENTE têm autorização para distribuição não-exclusiva da versão do trabalho publicada nesta revista.
O CEDENTE têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.