Aspectos gerais, virulência e resistência a medicamentos da Klebsiella pneumoniae: uma breve revisão

Ravenna Leite da  Silva; Andrea Fernanda Ramos de  Paula; Ana Isabele Andrade Neves; Bruna Araújo  Pires; Rafaela Oliveira  Nóbrega; Abrahão Alves de  Oliveira Filho

doi:10.18378/rebes.v14i3.10616

Authors

Ravenna Leite da Silva Universidade Federal da Paraíba, João Pessoa, Paraíba https://orcid.org/0000-0001-9270-0618
Andrea Fernanda Ramos de Paula Universidade Federal da Paraíba, João Pessoa, Paraíba https://orcid.org/0000-0002-3661-9513
Ana Isabele Andrade Neves Universidade Federal da Paraíba, João Pessoa, Paraíba https://orcid.org/0000-0003-2353-6548
Bruna Araújo Pires Universidade Federal da Paraíba, João Pessoa, Paraíba https://orcid.org/0000-0003-2579-8242
Rafaela Oliveira Nóbrega Universidade Federal da Paraíba, João Pessoa, Paraíba https://orcid.org/0000-0003-2303-9218
Abrahão Alves de Oliveira Filho Universidade Federal de Campina Grande, Patos, Paraíba https://orcid.org/0000-0002-7466-9933

DOI:

https://doi.org/10.18378/rebes.v14i3.10616

Keywords:

Bacteria, Bacterial infections, Microbiology

Abstract

Diseases related to pathogenic bacteria remain a significant threat to the human body. Among the main pathogenic bacteria that cause hospital infections, we find Klebsiella pneumoniae (KP), which is a Gram-negative bacillus belonging to the oral microbiota, routinely isolated in immunocompromised, hospitalized individuals with a underlying disease. Based on this, the aim of the work was to carry out a literature review on the general aspects, virulence and drug resistance of Klebsiella pneumoniae. KP can be categorized into classical KP (cKP) and hypervirulent KP (hvKP) according to its phenotypic and genotypic characteristics, the latter has greater virulence and can cause serious infectious diseases. Patients with K. pneumoniae infections have a tendency to metastatic dissemination to distant sites. The presentations of hvKP are diverse and distinct from infections caused by cKP. hvKP causes community-acquired invasive infections characterized by liver abscesses and metastatic infections of the lung, eyes, central nervous system, musculoskeletal system, and urinary tract. Antibacterials from the cephalosporin and carbapenem classes have been the mainstay of treatment for serious infections caused by KP, but their effectiveness has been compromised by the widespread acquisition of genes encoding enzymes such as extended-spectrum lactamases and carbapenemases. In view of this, it is extremely important to carry out studies addressing the current panorama of infections caused by KP and the mechanisms associated with the increase in its virulence and resistance to antimicrobials, bringing advantageous contributions and stimulating research into new pharmaceutical forms of antimicrobials.

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General aspects, virulence and drug resistance of Klebsiella pneumoniae: a brief review

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