Características clínicas, epidemiológicas e terapêuticas da Hemofilia A: Uma revisão de literatura.

Abstract

Hemophilia is a recessive genetic condition linked to the X chromosome, chronic and rare, characterized by alterations in the blood coagulation system that generates a permanent risk of spontaneous hemorrhage and its main clinical manifestation is hemorrhage. The objective of this literature review is to analyze the main aspects of Hemophilia A and B, highlighting Hemophilia A, addressing its clinical, epidemiological and therapeutic characteristics. The databases consulted that were used to form the methodology in this literature review were: Google Scholar, PubMed and Scielo (Scientific Electronic Library), all obtained via the internet, using the descriptors: “hemophilia A”, “literature review”, “factor VIII”, “epidemiological characteristics”, “therapeutic”, “clinical”. Hemophilia is a disease whose main clinical manifestation is hemorrhage present in the patient. Hemophilia A occurs in all geographic regions, ethnicities and groups socioeconomic factors, but there is a wide variation in its incidence and prevalence between countries, due to factors such as available treatment, case registration, access to diagnosis and associated mortality. Therapy focuses on the prevention and treatment of bleeding due to. deficiencies of clotting factors.