Medicamentos a base de plantas: ventajas y desventajas de su uso
DOI:
https://doi.org/10.18378/rebes.v13i4.10295Resumen
El uso de plantas medicinales está bastante extendido en la actualidad, siendo popular como una forma de medicina complementaria y alternativa en los países más desarrollados, mientras que las hierbas medicinales son drogas sintéticas, actuando tanto sobre el organismo humano como animal debido a los químicos que contienen, responsables de las actividades. A pesar de los numerosos beneficios de la aplicación de la medicina herbal en la medicina complementaria en muchos países, todavía hay mucho debate sobre los beneficios frente a los eventos adversos asociados con las aplicaciones de la medicina herbal, y se estima que se han reportado muy pocos eventos no deseados que han ocurrido. Por lo tanto, nuestro objetivo fue investigar los efectos adversos y beneficios del uso de medicamentos derivados de plantas. Farmacológico. El presente estudio es una revisión exploratoria de tipo bibliográfico. Se utilizaron las bases de datos de la BVS, que incluyeron LILACS, MEDLINE, IBECS, BDENF y CINAHL, Cochrane Library, SciELO, PubMed y Google Scholar. Se seleccionaron los siguientes descriptores: "Fármacos Fitoterapéuticos" Y "Efectos Secundarios y Reacciones Adversas Relacionados con Fármacos" Y "Seguridad". La OMS estima que más del 80% de la población mundial depende actualmente de las modalidades de curación tradicionales y a base de hierbas para la atención primaria de la salud y el bienestar. En la actualidad, existen miles de medicamentos a base de hierbas con numerosos beneficios, como los productos vegetales sintéticos y naturales con propiedades antioxidantes que se están explorando como posibles tratamientos para enfermedades neurodegenerativas. Por lo tanto, se debe tener precaución con su uso, ya que todavía existen numerosos problemas asociados con la seguridad, incluida la calidad del producto, las malas prácticas, las interacciones, los contaminantes y las toxicidades.
Descargas
Citas
AALTONEN, T. et al. Combined forward-backward asymmetry measurements in top-antitop quark production at the tevatron. Physical review letters, v. 120, n. 4, p. 042001, 2018.
ABEBE, D. Traditional medicine in Ethiopia: the attempts being made to promote it for effective and better utilization. Sinet, v. 9, n. Suppl., p. 61-69, 1986.
ACERO, N. et al. Phytotherapeutic alternatives for neurodegenerative dementias: Scientific review, discussion and therapeutic proposal. Phytotherapy Research, v. 37, n. 3, p. 1176-1211, 2023.
AHMAD, A. et al. Phytomedicine-based potent antioxidant, fisetin protects CNS-insult LPS-induced oxidative stress-mediated neurodegeneration and memory impairment. Journal of Clinical Medicine, v. 8, n. 6, p. 850, 2019.
ALLEGRA, S. et al. Phytotherapy and Drugs: Can Their Interactions Increase Side Effects in Cancer Patients?. Journal of Xenobiotics, v. 13, n. 1, p. 75-89, 2023.
ARKSEY, H.; O'MALLEY, L. Scoping studies: towards a methodological framework. International journal of social research methodology, v. 8, n. 1, p. 19-32, 2005.
BABAZADEH, A. et al. Natural bioactive molecules as neuromedicines for the treatment/prevention of neurodegenerative diseases. ACS omega, v. 8, n. 4, p. 3667-3683, 2023.
BEN‐ARYE, E. et al. Potential risks associated with traditional herbal medicine use in cancer care: A study of Middle Eastern oncology health care professionals. Cancer, v. 122, n. 4, p. 598-610, 2016.
BUDZIANOWSKI, J. Tobacco against Ebola Virus Disease, Przegl Lek, v. 72, n. 10, p. 567–571, 2015.
CHAN, T. Y. K. Interaction between warfarin and danshen (Salvia miltiorrhiza). Annals of Pharmacotherapy, v. 35, n. 4, p. 501-504, 2001.
CHÁVEZ-CASTILLO, M. et al. Exploring phytotherapeutic alternatives for obesity, insulin resistance and diabetes mellitus. Current Pharmaceutical Design, v. 26, n. 35, p. 4430-4443, 2020.
DAHL, S. Databank on phytochemistry and phytotherapy. Research & Reviews: A Journal of Bioinformatics, v. 7, n. 1, p. 31-51, 2020.
DJUV, A.; NILSEN, O. G.; STEINSBEKK, A. The co-use of conventional drugs and herbs among patients in Norwegian general practice: a cross-sectional study. BMC complementary and alternative medicine, v. 13, p. 1-11, 2013.
FÜRST, R.; ZÜNDORF, I. Evidence-based phytotherapy in Europe: where do we stand?. Planta medica, v. 81, n. 12/13, p. 962-967, 2015.
GUPTA, R. et al. Efficacy of phyto-therapeutics in allergic rhinitis: A review. Indian Journal of Natural Products and Resources (IJNPR)[Formerly Natural Product Radiance (NPR)], v. 13, n. 4, p. 451-459, 2023.
GURIB-FAKIM, A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular aspects of Medicine, v. 27, n. 1, p. 1-93, 2006.
IKRAM, M. et al. Natural dietary supplementation of curcumin protects mice brains against ethanol-induced oxidative stress-mediated neurodegeneration and memory impairment via Nrf2/TLR4/RAGE signaling. Nutrients, v. 11, n. 5, p. 1082, 2019.
ISLAM, F. et al. Bioactive compounds and their derivatives: an insight into prospective phytotherapeutic approach against alzheimer’s disease. Oxidative Medicine and Cellular Longevity, v. 2022, 2022.
JOANNA BRIGGS INSTITUTE. Joanna Briggs Institute Reviewers’ Manual. 2015 edn. Adelaide, South Australia: The Joanna Briggs Institute, 2015.
LYSS, G. et al. A sesquiterpene and sesquiterpene lactones from the Achillea millefolium group possess antiinflammatory properties but do not inhibit the transcription factor NF-kB. Pharmaceutical and Pharmacological Letters, v. 10, n. 1, p. 13-15, 2000.
MALINOWSKA, M.; BIELAWSKA, K. Metabolism and antioxidant properties of coumarins. Bromat. Chem. Toksykol, v. 3, p. 393–403, 2013.
MATSUDA, H. et al. Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: structure requirement and role of heat shock protein induction. Life Sciences, v. 66, n. 22, p. 2151-2157, 2000.
MAVONDO, G. A. et al. Malarial inflammation-driven pathophysiology and its attenuation by triterpene phytotherapeutics. Parasitol Microbiol Res, 2019.
MEISEL, C.; JOHNE, A.; ROOTS, I. Fatal intracerebral mass bleeding associated with Ginkgo biloba and ibuprofen. Atherosclerosis, v. 167, n. 2, p. 367, 2003.
NAWROT, J.; BUDZIANOWSKI, J.; NOWAK, G. Phytochemical profiles of the leaves of Stizolophus balsamita and Psephellus sibiricus and their chemotaxonomic implications. Phytochemistry, v. 159, p. 172-178, 2019.
NYE, M. B.; SCHWEBKE, J. R.; BODY, B. A. Comparison of APTIMA Trichomonas vaginalis transcription-mediated amplification to wet mount microscopy, culture, and polymerase chain reaction for diagnosis of trichomoniasis in men and women. American journal of obstetrics and gynecology, v. 200, n. 2, p. 188. e1-188. e7, 2009.
NYIRJESY, P.; SCHWEBKE, J. R. Secnidazole: next-generation antimicrobial agent for bacterial vaginosis treatment. Future microbiology, v. 13, n. 5, p. 507-524, 2018.
OLAKU, O.; WHITE, J. D. Herbal therapy use by cancer patients: a literature review on case reports. European journal of cancer, v. 47, n. 4, p. 508-514, 2011.
OLIVEIRA, D. R. A consolidação das práticas integrativas e complementares no século 21. VITTALLE-Revista de Ciências da Saúde, v. 30, n. 1, p. 7-8, 2018.
OMS. Organização Mundial da Saúde. Estratégia de Medicina Tradicional da OMS 2014e2023. Genebra: Organização Mundial da Saúde. 2013.
PAL, S. K.; S., Y. Herbal medicine: current status and the future. Asian pacific journal of cancer prevention, v. 4, n. 4, p. 281-288, 2003.
POHL, F.; LIN, P. K. T. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials. Molecules, v. 23, n. 12, p. 3283, 2018.
POOLE, D. N.; MCCLELLAND, R. S.. Global epidemiology of Trichomonas vaginalis. Sexually transmitted infections, v. 89, n. 6, p. 418-422, 2013.
PORTO, D. D.; Henriques, A. T.; Fett-Neto, A. G. Bioactive Alkaloids from South American Psychotria and Related Species, Open Bioactive Compound J, v. 2, p. 29-39, 2009.
ROUTLEDGE, P. A. The European Herbal Medicines Directive: could it have saved the lives of Romeo and Juliet?. Drug safety, v. 31, p. 416-418, 2008.
SALEHI, B. et al. Medicinal plants used in the treatment of human immunodeficiency virus. International journal of molecular sciences, v. 19, n. 5, p. 1459, 2018.
SAMUELSON, J.. Why metronidazole is active against both bacteria and parasites. Antimicrobial agents and chemotherapy, v. 43, n. 7, p. 1533-1541, 1999.
SCHWEBKE, J. R. et al. A phase-3, double-blind, placebo-controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis. American journal of obstetrics and gynecology, v. 217, n. 6, p. 678. e1-678. e9, 2017.
SENA, A. C. et al. Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention. Clinical infectious diseases, p. 13-22, 2007.
SHEEHY, O. et al. The use of metronidazole during pregnancy: a review of evidence. Current drug safety, v. 10, n. 2, p. 170-179, 2015.
SMITH, L.; ANGARONE, M. P. Sexually transmitted infections. Urologic Clinics, v. 42, n. 4, p. 507-518, 2015.
SOFOWORA, A. Research on medicinal plants and traditional medicine in Africa. The Journal of Alternative and Complementary Medicine, v. 2, n. 3, p. 365-372, 1996.
VAES, L. P. J.; Chyka, P. A. Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence. Annals of Pharmacotherapy, v. 34, n. 12, p. 1478-1482, 2000.
WENDEL, K. A.; WORKOWSKI, Kimberly A. Trichomoniasis: challenges to appropriate management. Clinical infectious diseases, v. 44, n. Supplement_3, p. S123-S129, 2007.
WHO. World Health Organization. Regulatory situation of herbal medicines: a worldwide review. 1998.
WHO. World Health Organization. Traditional Medicine Strategy 2002-2005 (WHO/EDM/TRM/2002.1). Geneva, Switzerland: World Health Organization; 2002.
YANG, S. et al. Trichomonas vaginalis infection-associated risk of cervical cancer: A meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology, v. 228, p. 166-173, 2018.
YIRGA, G.; TEFERI, M.; KASAYE, M. Survey of medicinal plants used to treat human ailments in Hawzen district, Northern Ethiopia. International Journal of Biodiversity and Conservation, v. 3, n. 13, p. 709-714, 2011.
ZHAO, B. Natural antioxidants for neurodegenerative diseases. Molecular neurobiology, v. 31, p. 283-293, 2005.
ZHOU, X. et al. Current status and major challenges to the safety and efficacy presented by Chinese herbal medicine. Medicines, v. 6, n. 1, p. 14, 2019.
Descargas
Publicado
Versiones
- 2023-12-22 (3)
- 2023-12-22 (2)
- 2023-12-22 (1)
Cómo citar
Número
Sección
Licencia
Derechos de autor 2023 Danton Dornelas Gontijo, Gabriela Alves Luz, Mariana Mendes Gonçalves Cimatti de Calasans, Izadora Farias Pereira, Ana Beatriz da Silva Barbosa, Camila Mageste Costa, Jonathan Jordão Diniz, Taianara Sampaio Reis
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Termo de cess
1.png)
milenanunes@fiponline.edu.br 
+55 83 988784633 (Milena Sousa)